Monocyte Activation Test Market Size, Share, Growth and Analysis 2034

Global Monocyte Activation Test Market Size- By Product, By Application, By Source, By End User - Regional Outlook, Competitive Strategies and Segment Forecast to 2034

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Published: Jun-2025	Report ID: HLCA25179	Pages: 1 - 256	Formats^*:
Category : Healthcare

Monocyte Activation Test Market Introduction and Overview

According to SPER Market Research, the Global Monocyte Activation Test Market is estimated to reach USD 2645.35 million by 2034 with a CAGR of 16.11%.

The report includes an in-depth analysis of the Global Monocyte Activation Test Market, including market size and trends, product mix, Applications, and supplier analysis. The Global Monocyte Activation Test Market was valued at USD 594 million in 2024 and is estimated to grow at a CAGR 16.11% from 2025 to 2034. As a reliable alternative to traditional pyrogen testing methods like the rabbit pyrogen test, the market for the Monocyte Activation Test (MAT) is growing. MAT is an in-vitro test that measures the release of cytokines from human monocytes to identify pyrogens in pharmaceutical goods, biologics, and medical devices. By minimizing animal research and producing precise, human-relevant data, it has ethical and scientific benefits. Because MAT complies with international pharmacopoeias and can be used in a variety of products, regulatory agencies are supporting it more and more. The focus on patient safety, expanding pharmaceutical R&D, and regulatory backing are the main factors driving the worldwide MAT market's expansion.

By Product Insights:

In 2024, the MAT Kits sector had the biggest market share. Particularly when testing for medications and medical equipment, the MAT is a highly accurate in vitro test for pyrogenicity determination. The MAT has supplanted more antiquated techniques such as the Limulus Amebocyte Lysate (LAL) test as the gold standard for endotoxin testing due to growing regulatory push for safer products. The MAT makes it possible to detect pyrogens more thoroughly, including ones that conventional endotoxin testing could miss. Its usage in medication development and production procedures, particularly for biologics and vaccines, is the result of this. The MAT, for instance, is frequently employed in the safety-critical testing of implanted devices and injectable medications.

By Application Insights:

In 2024, the segment that focused on drug development had the biggest share. A number of important considerations are driving the adoption of the Monocyte Activation Test (MAT) in drug development, making it a crucial tool for guaranteeing the safety of novel medications, especially biologics and vaccines. The growing regulatory need for more accurate and human-relevant pyrogen testing techniques is one of the main motivators. Because MAT offers a more realistic representation of human immune responses, regulatory bodies such as the FDA and EMA are increasingly choosing in vitro tests like MAT over conventional animal-based approaches for endotoxin testing.

By Source Insights:

The PBMC-based category held the largest proportion in 2024. Because it uses human immune cells to more closely mimic the human immunological response, the PBMC-based MAT is a more advanced and sensitive pyrogen testing method than traditional animal-based assays. One of the primary drivers is the increasing demand for more reliable and human-relevant testing methods. PBMC-based MAT offers a more physiologically realistic model since human cells are more representative of how individuals might respond to pyrogens. This is particularly important when testing biologics and vaccines because safety is the first priority.

By End User Insights:

The pharmaceutical industry segment maintained the largest market share in 2024. The Monocyte Activation Test (MAT) is becoming more and more crucial in the pharmaceutical business to guarantee the safety of medications, especially biologics and vaccines. One of the main motivators is the increasing regulatory focus on substituting more human-relevant in vitro techniques for animal testing. The results of MAT, which employs human immune cells, are more precise and repeatable than those of conventional animal-based endotoxin testing.

Regional Insights:

The North American monocyte activation test market was dominated in 2024 in part by the presence of respectable pharmaceutical and medical device industries. The implementation of MAT has been further stimulated by the region's emphasis on patient safety and quality control. The incorporation of MAT into industry operations has been facilitated by regulatory acceptance from entities like the Government of Canada and the United States Pharmacopeia (USP).

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Market Competitive Landscape:

Leading players in the Global Monocyte Activation Test market are focusing on R&D, regulatory compliance, and strategic collaborations to enhance test accuracy and scalability. Companies are expanding through product innovation, partnerships, and acquisitions to meet rising demand for reliable, non-animal pyrogen testing solutions. Some of the key market players are Bio-Rad Laboratories, Charles River Laboratories, Eurofins Scientific, Hyglos GmbH, Lonza Group, MAT BioTech, Merck KGaA, Seikagaku Corporation, Thermo Fisher Scientific, Wako Chemicals USA.

Recent Developments:

In June 2024, Merck KGaA's PyroMAT kit saw a rise in use worldwide, improving safety testing for medical devices and parenteral medications.

In October 2023, Lonza Group introduced the PyroCell MAT quick System and PyroCell MAT Human Serum Rapid System, two quick MAT platforms that use the PeliKine Human IL-6 Rapid ELISA Kit and cut the test duration from two days to two hours.

Scope of the report:

Report Metric	Details
Market size available for years	2021-2034
Base year considered	2024
Forecast period	2025-2034
Segments covered	By Product, By Application, By Source, By End User
Regions covered	North America, Latin America, Asia-Pacific, Europe, and Middle East & Africa
Companies Covered	Bio-Rad Laboratories, Charles River Laboratories, Eurofins Scientific, Hyglos GmbH, Lonza Group, MAT BioTech, Merck KGaA, Seikagaku Corporation, Thermo Fisher Scientific, Wako Chemicals USA.

Key Topics Covered in the Report:

Global Monocyte Activation Test Market Size (FY 2021-FY 2034)
Overview of Global Monocyte Activation Test Market
Segmentation of Global Monocyte Activation Test Market By Product (MAT Kits, Reagents)
Segmentation of Global Monocyte Activation Test Market By Application (Drug Development, Vaccine Development, Medical Device Testing, Others)
Segmentation of Global Monocyte Activation Test Market By Source (PBMC Based, Cell Line Based)
Segmentation of Global Monocyte Activation Test Market By End User (Pharmaceutical Industry, Biotechnology Industry, Medical Device Industry, Others)
Statistical Snap of Global Monocyte Activation Test Market
Expansion Analysis of Global Monocyte Activation Test Market
Problems and Obstacles in Global Monocyte Activation Test Market
Competitive Landscape in the Global Monocyte Activation Test Market
Details on Current Investment in Global Monocyte Activation Test Market
Competitive Analysis of Global Monocyte Activation Test Market
Prominent Players in the Global Monocyte Activation Test Market
SWOT Analysis of Global Monocyte Activation Test Market
Global Monocyte Activation Test Market Future Outlook and Projections (FY 2025-FY 2034)
Recommendations from Analyst

1. Introduction

1.1. Scope of the report
1.2. Market segment analysis

2. Research Methodology

2.1. Research data source

2.1.1. Secondary Data
2.1.2. Primary Data
2.1.3. SPERs internal database
2.1.4. Premium insight from KOLs

2.2. Market size estimation

2.2.1. Top-down and Bottom-up approach

2.3. Data triangulation

3. Executive Summary

4. Market Dynamics

4.1. Driver, Restraint, Opportunity and Challenges analysis

4.1.1. Drivers
4.1.2. Restraints
4.1.3. Opportunities
4.1.4. Challenges

5. Market variable and outlook

5.1. SWOT Analysis

5.1.1. Strengths
5.1.2. Weaknesses
5.1.3. Opportunities
5.1.4. Threats

5.2. PESTEL Analysis

5.2.1. Political Landscape
5.2.2. Economic Landscape
5.2.3. Social Landscape
5.2.4. Technological Landscape
5.2.5. Environmental Landscape
5.2.6. Legal Landscape

5.3. PORTERs Five Forces

5.3.1. Bargaining power of suppliers
5.3.2. Bargaining power of buyers
5.3.3. Threat of Substitute
5.3.4. Threat of new entrant
5.3.5. Competitive rivalry

5.4. Heat Map Analysis

6. Competitive Landscape

6.1. Global Monocyte Activation Test Market Manufacturing Base Distribution, Sales Area, Product Type
6.2. Mergers & Acquisitions, Partnerships, Product Launch, and Collaboration in Global Monocyte Activation Test Market

7. Global Monocyte Activation Test Market, By Product (USD Million) 2021-2034

7.1. MAT Kits
7.2. Reagents

8. Global Monocyte Activation Test Market, By Application (USD Million) 2021-2034

8.1. Drug Development
8.2. Vaccine Development
8.3. Medical Device Testing
8.4. Others

9. Global Monocyte Activation Test Market, By Source (USD Million) 2021-2034

9.1. PBMC Based
9.2. Cell Line Based

10. Global Monocyte Activation Test Market, By End User (USD Million) 2021-2034

10.1. Pharmaceutical Industry
10.2. Biotechnology Industry
10.3. Medical Device Industry
10.4. Others

11. Global Monocyte Activation Test Market, (USD Million) 2021-2034

11.1. Global Monocyte Activation Test Market Size and Market Share

12. Global Monocyte Activation Test Market, By Region, (USD Million) 2021-2034

12.1. Asia-Pacific

12.1.1. Australia
12.1.2. China
12.1.3. India
12.1.4. Japan
12.1.5. South Korea
12.1.6. Rest of Asia-Pacific

12.2. Europe

12.2.1. France
12.2.2. Germany
12.2.3. Italy
12.2.4. Spain
12.2.5. United Kingdom
12.2.6. Rest of Europe

12.3. Middle East and Africa

12.3.1. Kingdom of Saudi Arabia
12.3.2. United Arab Emirates
12.3.3. Qatar
12.3.4. South Africa
12.3.5. Egypt
12.3.6. Morocco
12.3.7. Nigeria
12.3.8. Rest of Middle-East and Africa

12.4. North America

12.4.1. Canada
12.4.2. Mexico
12.4.3. United States

12.5. Latin America

12.5.1. Argentina
12.5.2. Brazil
12.5.3. Rest of Latin America

13. Company Profile

13.1. Bio-Rad Laboratories

13.1.1. Company details
13.1.2. Financial outlook
13.1.3. Product summary
13.1.4. Recent developments

13.2. Charles River Laboratories

13.2.1. Company details
13.2.2. Financial outlook
13.2.3. Product summary
13.2.4. Recent developments

13.3. Eurofins Scientific

13.3.1. Company details
13.3.2. Financial outlook
13.3.3. Product summary
13.3.4. Recent developments

13.4. Hyglos GmbH

13.4.1. Company details
13.4.2. Financial outlook
13.4.3. Product summary
13.4.4. Recent developments

13.5. Lonza Group

13.5.1. Company details
13.5.2. Financial outlook
13.5.3. Product summary
13.5.4. Recent developments

13.6. MAT BioTech

13.6.1. Company details
13.6.2. Financial outlook
13.6.3. Product summary
13.6.4. Recent developments

13.7. Merck KGaA

13.7.1. Company details
13.7.2. Financial outlook
13.7.3. Product summary
13.7.4. Recent developments

13.8. Seikagaku Corporation

13.8.1. Company details
13.8.2. Financial outlook
13.8.3. Product summary
13.8.4. Recent developments

13.9. Thermo Fisher Scientific

13.9.1. Company details
13.9.2. Financial outlook
13.9.3. Product summary
13.9.4. Recent developments

13.10. Wako Chemicals USA

13.10.1. Company details
13.10.2. Financial outlook
13.10.3. Product summary
13.10.4. Recent developments

13.11. Others

14. Conclusion

15. List of Abbreviations

16. Reference Links

SPER Market Research’s methodology uses great emphasis on primary research to ensure that the market intelligence insights are up to date, reliable and accurate. Primary interviews are done with players involved in each phase of a supply chain to analyze the market forecasting. The secondary research method is used to help you fully understand how the future markets and the spending patterns look likes.

The report is based on in-depth qualitative and quantitative analysis of the Product Market. The quantitative analysis involves the application of various projection and sampling techniques. The qualitative analysis involves primary interviews, surveys, and vendor briefings. The data gathered as a result of these processes are validated through experts opinion. Our research methodology entails an ideal mixture of primary and secondary initiatives.

SPER-Methodology-1

SPER-Methodology-2

SPER-Methodology-3

Frequently Asked Questions About This Report

How big is the Monocyte Activation Test Market?

Monocyte Activation Test Market is projected to reach USD 2645.35 million by 2034, growing at a CAGR of of 16.11% during the forecast period.

What is the growth rate of the Monocyte Activation Test Market ?

Monocyte Activation Test Market grew in Market size from 2025. The Market is expected to reach USD 2645.35 million by 2034, at a CAGR of 16.11% during the forecast period.

What is the anticipated CAGR of the Monocyte Activation Test Market ?

Monocyte Activation Test Market CAGR of 16.11% during the forecast period.

How can I get a sample report on the Monocyte Activation Test Market ?

You can get the sample pages by clicking the link - Click Here

What is the Market size of the Monocyte Activation Test Market ?

Monocyte Activation Test Market size is USD 2645.35 million from 2025 to 2034.

Which segment is expected to Monocyte Activation Test Market ?

Monocyte Activation Test Market is covered By Product, By Application, By Source, By End User

Which region is expected to have the highest Market share in the Monocyte Activation Test Market ?

The North America, Latin America, Asia-Pacific, Europe, and Middle East & Africa and Europe is the highest Market share in the Monocyte Activation Test Market .

Who are the key players in Monocyte Activation Test Market ?

Bio-Rad Laboratories, Charles River Laboratories, Eurofins Scientific, Hyglos GmbH, Lonza Group, MAT BioTech, Merck KGaA, Seikagaku Corporation, Thermo Fisher Scientific, Wako Chemicals USA.

What is the conclusion of the Monocyte Activation Test Market ?

The report includes an in-depth analysis of the Global Monocyte Activation Test Market, including market size and trends, product mix, Applications, and supplier analysis.